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The jieduan-niwan (Jdnw) formula ameliorates hepatocyte apoptosis: A study of the inhibition of E2f1-mediated apoptosis signaling pathways in acute-on-chronic liver failure (Aclf) using rats

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122 While methimazole has been reported as an inhibitor of FMO3, its clinical use is primarily as an antithyroid medication, and it has severe hepatotoxic side effects, eliminating it from reasonable contention in the treatment of elevated TMAO

Both radiographic and clinical benefit were sustained through 1 year as patients transitioned to open-label therapy after 24 weeks