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Call your healthcare provider right away if you have leg pain that does not go away, sudden shortness of breath, sudden blindness (partial or complete), severe pain or pressure in your chest, sudden, severe headache unlike your usual headaches, weakness or numbness in an arm or leg, or trouble speaking, or yellowing of the skin or eyeballs

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showed that thiamine effectively protects grapevines against Plasmopara viticola through a dual action mode of direct antifungal activity and inducing the host to produce direct and primed defense mechanisms 57