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Treatment of adipocytes isolated from HSL-null mice with the beta-adrenergic agonist isoproterenol causes enhanced lipolysis, albeit at a blunted level compared with adipocytes from wild-type animals (91)

This is a completely normal part of aging, but its something to be aware of, especially if you start noticing symptoms like fatigue or mental fogginess

Many users choose to continue therapy long-term at maintenance doses rather than discontinuing

Whilst these compounds have established biochemical functions, there is no robust randomised controlled trial evidence for clinically meaningful weight loss or fat reduction in replete individuals