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Despite the lack of meal dependency at the injection level, the GLP-1 and GIP receptor components of retatrutide do interact meaningfully with postprandial physiology

Cagrilintide was specifically engineered with molecular modifications to resist rapid breakdown in the body and bind effectively to amylin 1 and 3 (AMY1R, AMY3R) receptors in the brain, allowing for a more stable, once-weekly dosing regimen compared to the multiple daily injections required for older amylin analogues like pramlintide