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Many patients pursue Sermorelin when they feel they are not recovering as well as they used to, are seeing changes in body composition, or want a more natural-feeling approach than direct hormone replacement

Stage IV

Secretome engineering is an emerging frontier: PD-MSCs primed to secrete high hepatocyte-growth-factor engage Wnt/-catenin signalling to tighten endothelial barriers and foster follicular growth [183], while an estrogen-responsive PD-MSC secretome rescues cyclophosphamide-induced POI, restores circadian clock genes and curbs granulosa-cell apoptosis, suggesting cell-free formulations could combine ovarian repair with systemic chronoprotection [20]