Developing advanced biologics and immunotherapies for allergy management
First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate
First, we tested how the sensor responded to the exogenous addition of high concentrations of either the oxidant diamide or the reductant dithiothreitol (DTT) (Figure 1A)
Oxidative stress and reproductive function: oxidative stress in polycystic ovary syndrome