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49 Elevated inflammatory factors in T2D such as IL-6 and interferon- (IFN-) cand bind to their receptors, activate JAK2/STAT3, subsequently upregulates the expression of suppressor of cytokine signaling 3 (SOCS3), which inhibit IRS-1 cascade

The course of BD is also intensified by other comorbid psychiatric disorders [14] such as anxiety disorders [15], attention deficit hyperactivity disorder (ADHD) [16], alcohol use disorder (AUD), substance use disorder [17], and binge eating disorder [18], as well as cognitive impairment [19], implying a potential intersection of their pathogenesis

The dietary restriction of AGE, in fact, is associated with a significant reduction in inflammatory markers, such as plasma CRP, TNF- (tumor necrosis factor-) and VCAM-1 (vascular cell adhesion molecule-1) [59]

The potential uses of omega-3 fatty acids in dermatology: a review