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In the Valsartan in Acute Myocardial Infarction Trial (VALIANT), hypotension in post-myocardial infarction patients led to permanent discontinuation of therapy in 1.4% of valsartan-treated patients and 0.8% of captopril-treated patients

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In normal aging, BBB breakdown could only be found in the hippocampal CA1 region and the dentate gyrus, and histological alterations like thickening of the basement membrane are also restricted to specific brain regions [275]