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Studies have demonstrated that mast cell-deficient models of MS exhibit reduced disease severity, highlighting their pathological role in central nervous system autoimmunity

A minimum quantity of 20,000 cells per sample was collected, and the DNA histograms were further analyzed using the ModFit LT software (Verity Software House, Topsham, ME, USA) for cell cycle analysis

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This framework is particularly useful, for example, in the search for repressor mutants that uncouple metal and DNA binding to variable degrees ( G c ), thus providing fundamental insights into the mechanism of allosteric connectivity