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Mitochondrial stress can also be triggered by excessive Ca 2+ accumulation, which disrupts mitochondrial membrane potential and initiates cell death

However, most of these self-reactive T cells do not cause any problems as they are suppressed by fetal regulatory T cells (Tregs) (Burt, IUSCT Experimental Studies The notion of using the fetus as the recipient of stem cell transplantation traces back to the landmark finding that exposure to foreign antigens can result in immune tolerance

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