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Compared with the control group, the apoptosis rate and early apoptosis rate of EPCs in the CTPB group were higher, indicating that CTPB might decrease EPCs proliferation by increasing the relative expression of p300 protein

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We note that in prior rulemaking, for example, in the CY 2013 PFS final rule, we stated, we further consider[ed] how advanced primary care practices can fit within a fee-for-service model (77 FR 68987), and in the CY 2015 PFS final rule, we stated our commitment to supporting advanced primary care, including the recognition of care management as one of the critical components of primary care that contributes to better health for individuals and reduced expenditure growth (79 FR 67715)