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Gut Microbes 16(1):2392009 Giugliano S, Gatti A, Rusin M, Schorn T, Pimazzoni S, Calanni-Pileri M, Fraccascia V, Carloni S, Rescigno M (2025) Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome

This hypothesis is in line with a previous study showing the absence of cntA expression in human fecal samples (Rath et al., 2018) or with another investigation that demonstrated poor correlation between cntA abundance and TMAO plasma levels (Wu et al., 2019)

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The reduction in SCFAs contributes to heightened inflammation and compromised gut barrier function