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A pooled analysis published in the National Institutes of Health PMC archive found tirzepatide reduced body weight more than semaglutide across different study designs, and a journal review summarized by the American College of Cardiology reported significantly greater weight loss with tirzepatide

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J Chem Neuroanat 112:101915

These are frequently warned about due to their hypertensive effects, which are caused by their interactions with the mineralocorticoid receptors in the adrenal glands