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In db/db mice, previous studies found that AMPK activation could reduce ROS production and increase mitochondrial biogenesis and ETC activity to alleviate kidney damage in diabetic models[150, 151]

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In mesothelioma models, SFN disrupts PRMT5/MEP50 complex function, inhibiting its methyltransferase activity, reactivating tumor suppressor expression, and suppressing cancer cell proliferation, invasion, and stem-like properties (79, 80)