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As for peptides, they are generally well-tolerated, but its always best to do a patch test before using them all over your face

Some researchers also include supportive supplements alongside peptide protocols: quercetin as a natural mast cell stabilizer, vitamin D for immune regulation, and omega-3 fatty acids for anti-inflammatory support

62,63 However, one underlying mechanism is the phosphorylation of Rho A, which inhibits Rho kinase, thereby activating myosin light chain phosphatase, which in turn leads to smooth muscle cell relaxation