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A basis for further research and the formulation of new polyphenol-based health nutrition products has been laid by the introduction of some commercialized functionalized polyphenol products to the market

(2017) MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer, EMBO Rep

In addition, bacterial infection, tissue hypoxia, and other pathological processes, drugs, ionizing radiation, and other exogenous factors can also lead to a large number of intracellular ROS ( Keap1-dependent Nrf2 Regulation Keap1 was an efficient sensor for redox reaction containing broad complex-tramtrack-bric-a-brac (BTB) domain, intermediate region (IVR), double glycine repeat (DGR), and carboxyl terminal region (CTR)

This sensitivity to DNA-damaging agents was not rescued by KG, l-carnitine or acetylcarnitine (Extended Data Fig