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CMS publishes updated MUE tables quarterly through its CMS Medically Unlikely Edits, Q2 2026 page

Model: Female US NIH National Institute on Aging (NIA) Aged Rodent Colony mice aged 22 months Dosage: 10 mg/kg of 5-amino-1MQ administered with subcutaneous injections for eight weeks

Vitamin B12-related acne tends to occur only in dosages in excess of 5 to 10 mg per week. Thats 5,000 to 10,000 micrograms a week, which is well in excess of the 50 micrograms a day or, alternately, the 2,000-microgram single weekly dose that I recommend

That broader claim is not formally recognized , and it should be presented candidly as such