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In line with this concept - other than system Xc- inhibitors - dexamethasone only affected ferroptosis induction via FINO2, a drug which iron-dependently generates ROS, but not with other canonical ferroptosis inducers such as direct GPX4 inhibitors

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on 18 patients with PV (12 males, 6 females) and 18 healthy volunteers found a significant reduction in plasma and RBC GSH-Px and catalase activity and GSH value and increase in plasma MDA level in patients with pemphigus vulgaris.[] ERECTILE DYSFUNCTION The reduced form of glutathione is essential cofactor for NO synthase that catalyzes synthesis of NO from L-arginine in the endothelium