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An intravenous formulation of NAC (trade name Acetadote), FDA-approved in 2004, is reserved for patients with altered mental status, gastrointestinal bleeding, history of a caustic ingestion, or refractory emesis despite the use of antiemetics

Ali SA, Faddah L, Abdel-Baky A, Bayoumi A (2010) Protective effect of L-carnitine and coenzyme Q10 on CCl-induced liver injury in rats

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Considering that mice show ~7-fold higher metabolic turnover, this in vivo study represents a treatment model that is achievable for the treatment of patients with NSCLC in the clinic