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The fluorescent protein-tagged marker of the endoplasmic reticulum (mCherry-Sec61-N-18), mitochondrial (mCherry-TOMM20-N-10), and Golgi apparatus (pmScarlet_Giantin_C1) were gifts from Michael Davidson (Addgene plasmid # 55130 and #55146) and Dorus Gadella (Addgene plasmid # 85048), respectively

Surface defects and aggregation are other factors which could contribute to the fluorescence quenching of CQDs due to unwanted electronic states of higher density which trap photo-excited carriers, enhancing non-radiative decays [108]

JAS was funded for this work through grants from the NIH/NIDDK K08DK124449, R03DK138962