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The total number of people living with biological Alzheimer's disease is larger than the number with MCI or dementia due to Alzheimer's disease given that there is an incipient and silent (i.e., preclinical) stage of Alzheimer's disease before the emergence of cognitive symptoms of either MCI or dementia

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The numerous CF animal models that develop airway disease similar to humans [162,163,164,165], as well as the multiple small molecules available that inhibit or potentiate NPY signaling [182, 189] offer ample opportunities to investigate the potential role of NPY in CF

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