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In a process called glutathione conjugation, catalysed by glutathione S-transferase (GST) enzymes, glutathione binds directly to fat-soluble toxins and converts them into water-soluble compounds that can be safely excreted via bile or urine

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In vivo studies using xenograft models in nude mice showed that tumor growth inhibition or regression was positively corelated with GSTP1-1 expression levels in response to TLK286 treatment, and a mild bone marrow toxicity was observed as a side effect [111]

Ozkaya O, Mekin S, Hakan K