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Vitamin B12 is a nutrient commonly found in animal-based foods, so individuals who follow a vegetarian or vegan diet may be at a higher risk for Vitamin B12 deficiency

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Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate