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Then, QCT could suppress the Erastin-induced elevation in the phosphorylated AKT (pAKT) to AKT ratio and attenuated the reduction in GPX4 expression, which was not exerted by QCT after down-regulation of EGFR

[ 31 , 255 ] Of even greater significance is the research demonstrating that siRNAmediated downregulation of BACH1 diminishes the expression of EMT and prometastatic factors, thereby suppressing the metastasis of breast or colon cancer