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A metabolite of acetaminophen also acts on the TRPV1 and TRPA1 receptors to decrease pain.[ref] While generally safe when taken as directed, higher doses of acetaminophen can lead to severe liver damage and potentially fatal liver failure

105 Historically considered to be cytosolic, CBS and CSE can alsounder certain (patho)physiological conditionstranslocate to mitochondria 108,109 or nuclei, 110 or even be secreted

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