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Ultra-mutation in IDH wild-type glioblastomas of patients younger than 55 years is associated with defective mismatch repair, microsatellite instability, and giant cell enrichment

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Phenotypic Screening Deconvolution After a phenotypic screen identifies active compounds, metabolic fingerprinting provides the first mechanistic triage layer separating compounds that act through energy metabolism, membrane disruption, nucleotide biosynthesis, or signalling pathway inhibition without requiring individual target binding assays