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Superoxide radical and hydroperoxyl radical An important electron transfer reaction occurs in mitochondria via leakage of an electron from the electron transfer chain to oxygen during oxidative phosphorylation, resulting in the formation of a primary radical, superoxide radical anion (O 2 + e O 2 ) (Boveris and Cadenas 1982)

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Neuropathic pain worsens cognitive and mood functions and quality of life and is treated with antiepileptic and/or antidepressant drugs targeting the abnormal somatosensory nervous systems (Nicholson and Verma, 2004

Recent studies have increasingly focused on the role of ferroptosis in the pathophysiology of depression