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Taking the right to health as the starting point, signatories to the FCTC and the WHO have a responsibility to take positive steps to ensure that safer alternatives are available to the 1.1 billion smokers worldwide

In further sub-group analyses, the association was significant in the studies that used the standardized ISAAC protocol (RR = 1.50, 95% CI 1.351.66), but not those that used their own protocol (RR = 0.96, 95% CI 0.881.08)

[PubMed: 16567058] Cawley J, Markowitz S, Tauras J

However, allergies are often considered to be an overreaction of the immune system, producing histamine in the absence of an actually threatening foreign substance