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Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)

Protein glutathionylation in erythrocytes

It also participates in energy metabolism, specifically in the conversion of food into usable cellular energy

CBS and CSE have been reported to re-localise to mitochondria in response to hypoxia, a common feature of the tumour microenvironment, resulting in targeted H 2 S delivery that can stimulate ATP production and protect mitochondria from oxidative stress