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The combination is synergistic because BPC-157 and TB-500 address complementary stages of the healing cascade: Phase 1, Inflammation (Days 1-5): TB-500 suppresses the inflammatory cytokine response while BPC-157 begins upregulating growth factor signaling at the injury site

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Under pathological conditions, disruption of TFAM can lead to mtDNA mispackaging, a massive release of damaged mtDNA, and down-regulation of TFAM also reduces the stability of the mtDNA mimetic nuclear structure (West et al., 2015)