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NCOA4 expression was found to be increased during the peak and progressive phases of chronic maximum coping effort EAE, accompanied by an elevation in redox-active ferrous iron

However, this process also creates inflammation and oxidative byproducts

CRISPR-Cas9-mediated genome editing has successfully generated Brassica varieties with significantly increased glucoraphanin accumulation by modulating key genes in the pathway, including MYB28, AOP2, and BCAT4 (96, 107)

The selected dose of 120 mg/kg body weight is a well-established one for inducing significant and consistent testicular oxidative stress and spermatotoxicity in rodent models, as extensively documented in the literature 39