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In comparison with GLS inhibitors, a paucity of research has been conducted on GDH inhibitors, and there are no drug currently available for clinical application

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doi: 10.3389/fmolb.2025.1724944 Received 14 October 2025 Revised 18 November 2025 Accepted 30 November 2025 Published 18 December 2025 Volume 12 - 2025 Edited by Maria Barile, University of Bari Aldo Moro, Italy Reviewed by Anna Maria Giudetti, University of Salento, Italy Maria Tolomeo, National Research Council (CNR), Italy Updates Copyright 2025 Schrder, Jalilvand, Kahl, Kaiser and Liebau

Topical treatments are usually first-line: Over-the-counter topical creams containing benzoyl peroxide or salicylic acid can reduce bacteria and inflammation when applied consistently