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Category C : Risk couldnt be ruled out, with adverse effects seen in animal studies but insufficient human data

One potential issue associated with high doses of folic acid is that it has a masking effect on the diagnosis of pernicious anaemia due to vitamin B 12 deficiency, and may even precipitate or exacerbate neuropathy in vitamin B12-deficient individuals

A comparative study on the efficacy of coenzyme Q10 and amitriptyline in the prophylactic treatment of migraine headaches in children: a randomized controlled trial

AOD-9604 has been studied extensively in both preclinical animal models and human clinical trials involving approximately 900 participants