doi:10.1016/j.freeradbiomed.2014.01.009 Go YM, Jones DP (2011) Cysteine/cystine redox signaling in cardiovascular disease
Providing that it may be induced rapidly, and then persisting for hour and day periods, this damaging effect is obviously part and parcel of general NSAIDs-toxicity, including gastric and small intestine ulcers, hepatotoxicity and encephalopathy (3, 8-14)
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Studies have explored its potential involvement in nitric oxide (NO) signaling, growth factor modulation (including VEGF, FGF2, and EGF receptor pathways), and FAK-paxillin pathway activation