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However, it should be carefully noted that the very limited number of human trials have made no specific mention of adverse reactions

Tramadol abuse, with its risk of physical dependence, opiate use disorder and overdoses, is of concern worldwide and has led to it being a controlled drug in many countries

Self-reported cognitive impairment in individuals with Primary Immunodeficiency Disease

Nat Rev Genet 10:233240 Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH (2011) FoxO6 integrates insulin signaling with gluconeogenesis in the liver