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We discuss how ME/CFS emerges from an intricate web of genetic vulnerabilities and environmental triggers, notably viral infections, leading to a complex series of pathological responses including immune dysregulation, chronic inflammation, gut dysbiosis, and metabolic disturbances

Intriguingly, two other Tdf proteins are present in pathogenic but in none of the commensal Neisseria species, TdfF and TdfG (Marri et al., 2010), suggesting a key role in virulence

For cloning of the MCP transfer vector, the first 215 aa of the N-terminal MCP sequence were truncated and replaced by a glutathione-S-transferase (GST)-tag

In conclusion, nutrients provide safe non-pharmaceutical depression interventions [e.g., 2 weekly oily fish, 2530 g/day fiber]