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The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication

10.1007/s10930-022-10074-5 13 HepsomaliP.GroegerJ

Was telomere length measured with a validated method

The integration of metagenomics, metabolomics, and host immunologic and metabolic profilingapproaches that have been increasingly highlighted in human probiotic trials and precision nutrition studies conducted between 2023 and 2025 will be pivotal in understanding the mechanisms that distinguish responders from non-responders and in developing validated predictive biomarkers to inform personalized probiotic selection (581)