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Thus their use makes much more sense

This breadth of action distinguishes it from growth factors with a narrow receptor focus and helps explain experimentally observed tissue protection across different organ systems

183 The ADP-ribosylation of histones by PARP-1 induces the dissociation of nucleosomes, leading to the decompaction of chromatin

Thats a mechanistically different target than NSAIDs (nonsteroidal anti-inflammatory drugs), or corticosteroids, which partly explains why the compound has attracted interest in cases where conventional anti-inflammatory approaches have failed or created downstream problems