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TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells

Research shows systemic effects require milligram-range dosing for GHK-Cu, while BPC-157 and TB-500 show activity at lower concentrations

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Then, by changing the surface properties of the MAPHP-particle system through coating surfactants (e.g., T80), by overcoating with ApoE, B, A-I or by complexing with iron, the system could mimic the behavior of the apolipoprotein E- (ApoE) and apolipoprotein A-I (ApoA-I)-NPs, respectively, so as to cross the BBB and take the excess metals out of the brain with very limited toxicity (Davson and Segal, 1995