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Moreover, Wnt2 genes found in the autism susceptibility chromosomal locus and several Wnt2 variants are associated with ASD [178,179,180,181,182]

They consist of integral transmembrane proteins that include occludin, tricellulin, claudins, and junctional adhesion molecules (JAMs) and peripheral proteins known as zonula occludens (ZO-1, ZO-2, ZO-3), which bind to actin filaments (Figure 4) [22,23]

When both are activated simultaneously, the intracellular signalling cascades interact synergistically: CJC-1295 activates GHRHR increases intracellular cAMP activates protein kinase A enhances GH gene transcription and vesicle exocytosis

Ohtake Y, Watanabe K, Tezuka H, Ogata T, Yabuuchi S, Murata K, et al