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In addition, sulforaphane inhibited rotenone-induced neuronal apoptosis, as detected by the protein expression of cleaved-caspase-3 in the SH-SY5Y cell line (Fig

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This was accomplished by screening a library of small molecule drugs that exhibited selective lethality in RAS-mutated cancer cell lines, thereby introducing a new non-apoptotic mechanism of cell death ( 2.2 Mechanism of ferroptosis The sources of lipid ROS that induce ferroptosis are multifaceted, and lipid peroxidation pathways and iron metabolism are increasingly considered to be involved in the ferroptosis process (Figure 1)