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The rationale is that effects accumulate during the course and persist between courses, with new courses reinforcing the previous effects

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Although the pathology in CAE was mainly targeted to the corpus callosum where cuprizone-mediated white matter injury is focused, very prominent lymphocytic inflammation, demyelination and axonal injury were observed that closely resembled an active MS lesion

Common ingredients include methionine, inositol, choline (collectively known as MIC), and often B vitamins including B12