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Shaking creates shearing forces and foam, which can denature the peptide chains, essentially ripping the complex folded structure apart

The medication is eliminated primarily through proteolytic degradationmeaning it is broken down by enzymes into smaller peptide fragments and amino acids, which are then processed through normal metabolic pathways

[2] In addition to actions at receptors, Semax, as well as a related peptide drug, Selank, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides (IC 50 = 10 M), though the clinical significance of this property is uncertain

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