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Diabetes 70 , 25452553 (2021)

(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug

It not only scavenges free radicals that can trigger excess melanin production, but it also influences the melanin-making process itself (more on that in the next section)