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1 NAFLD is most commonly diagnosed in overweight and obese individuals, particularly those with metabolic syndromes including type 2 diabetes (T2D) and dyslipidemia

It is characterized by an acid pH (induced by vacuolar ATPase, which pumps protons into it) and many proteases (such as cathepsins) responsible for its proteolytic degradation ( In addition to sequestering the parasite in an inhospitable terrain such as the interior of a phagolysosome, macrophages produce a variety of toxic compounds that help to destroy the phagocytosed microorganism: nitric oxide (NO), and ROS

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The biological activity of CRMP2 depends on posttranslational modifications