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These previous studies [12,13,14,15,16,17] had several limitations such as the inclusion of relatively small number of cases, especially for rare type of congenital anomalies (i.e., being underpowered to detect small or moderate risk effect), the use of case-control design (i.e., being more prone to selection bias), or insufficient adjustment for potential confounders (i.e., being more prone to confounding bias)

doi: 10.1016/j.esxm.2018.02.001

"There may be some rules with the FDA, but these companies are not necessarily following them." Marousek noted that in 2010, the Food and Drug Administration issued warning letters to five electronic cigarette distributors for unsubstantiated claims and poor manufacturing practices