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doi: 10.1242/dmm.006775

Apparently, the concentration of riboflavin in the medium should be lower than 12.76 nmol/L in order to induce a significant change in cell viability and apoptosis

Science 247 , 14651468 (1990)

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)