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MTX was shown to inhibit methionine S-adenosyltransferase (MAT) gene expression, protein levels amounts and activity in vitro and in vivo , resulting in decreased levels of S-adenosylmethionine (SAM) (30), the main methyl donor of metabolism

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The recent surge of the application of AI methods in biomedical research showcases the potential as a promising designer candidate for in-depth investigations of therapeutic peptides [194196], Bhardwajs [194] and Mas group [196] have demonstrated the feasibility of using machine learning methods to achieve de novo design of cell-penetrating macrocycles and accurate design of AMPs