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Toxic doses in research have been measured at 300-3,750 times higher than therapeutic ranges, providing substantial safety margins

Anti-inflammatory effects can limit immune-mediated tissue damage, while enhanced blood flow and tissue regeneration may accelerate healing of mild intestinal lesions or irritation

The estimated mean change in body weight at week 68 was 20.4% with CagriSema versus 3.0% with placebo (a difference of about 17 percentage points), and more CagriSema participants reached weight-loss thresholds of 5%, 20%, 25%, and 30% than placebo

The standard initial loading dose is 1,000 mcg administered intramuscularly (IM) once weekly for 4 weeks