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Andrew Salner, MD, is medical director of the Hartford HealthCare Cancer Institute at Hartford Hospital and serves on the CT Medical Marijuana Program Physician Advisory Board

[46] However, evidence has emerged that nicotine may suppress the growth inhibitory effects of trans-retinoic acid (RA) on lung cancer cells by inhibiting retinoic acid receptor (RAR) expression by inducing expression of an orphan RA receptor TR3, while inhibition of lung cancer cells by retinoid X receptor-selective (RXR-selective) retinoids was unaffected by nicotine. [47] These findings when coupled together suggest that when acting through specific nAchRs expressed in lung epithelial cells, nicotine, as well as compounds such as NNK that can be formed by exposure to nicotine, may help to expedite the pathogenesis of lung cancer in humans

A representative of the alliance testified in a recent committee hearing on the measure that it would hurt small businesses that are struggling to recover during the COVID-19 pandemic and deprive the state of needed tax revenue

Purchasing cartons reduces the per-cigarette cost and remains the most common option for frequent smokers